Researchers have developed a passive air sampler clip that can help assess personal exposure to SARS-CoV-2.

The wearable passive air sampler developed by researchers from Yale University (New Haven, CT, USA) could be especially helpful for workers in high-risk settings, such as restaurants or health care facilities.

COVID-19 is primarily transmitted through the inhalation of virus-laden aerosols and respiratory droplets that infected individuals expel by coughing, sneezing, speaking or breathing. Researchers have used active air sampling devices to detect airborne SARS-CoV-2 in indoor settings; however, these monitors are typically large, expensive, non-portable and require electricity. To better understand personal exposures to the virus, the researchers wanted to develop a small, lightweight, inexpensive and wearable device that does not require a power source.

The new wearable passive air sampler, known as the Fresh Air Clip, continually adsorbs virus-laden aerosols on a polydimethylsiloxane (PDMS) surface. The team tested the air sampler in a rotating drum in which they generated aerosols containing a surrogate virus, a bacteriophage with similar properties to SARS-CoV-2. They detected virus on the PDMS sampler using the polymerase chain reaction (PCR), showing that the device could be used to reliably estimate airborne virus concentrations.

Then, the researchers distributed Fresh Air Clips to 62 volunteers, who wore the monitors for five days. PCR analysis of the clips detected SARS-CoV-2 RNA in five of the clips: Four were worn by restaurant servers and one by a homeless shelter staff person. The highest viral loads (more than 100 RNA copies per clip) were detected in two badges from restaurant servers.

Although the Fresh Air Clip has not yet been commercialized, these results indicate that it could serve as a semi-quantitative screening tool for assessing personal exposure to SARS-CoV-2, as well as help identify high-risk areas for indoor exposure, according to the researchers. 

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