The researchers propose that a better appreciation of the relationship between exercise, mood, and the endocannabinoid system could result in better treatments for depression.

The study investigated changes in mood and endocannabinoid levels in people with major depression who exercised at different intensities on a stationary bike.

The investigators found a significant increase in endocannabinoid levels and improvement in mood after a session of prescribed exercise of moderate intensity.

The endocannabinoid system is a cell signaling system comprising the body's own cannabinoids, or endocannabinoids, and receptors. It extends throughout the body and influences the function of the immune, cardiovascular, and nervous systems.

When a particular endocannabinoid binds to a matching cell receptor, it sends a signal into the cell that alters its behavior and functioning.

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