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News Center
Is this red wine compound the future of depression treatment?
In the United States and further afield, anxiety and depression are substantial challenges.
About 1 in 5 adults in the United States have experienced an anxiety disorder in the past year.
In addition, an estimated 7.1% of adults experienced a major depressive episode in 2017.
Some people who have anxiety or depression may benefit from medications, but they do not work for everyone.
As the authors of the current study write, "only one-third of individuals with depression or anxiety show full remission in response to these medications."
For this reason, researchers are keen to find new drugs to treat depression and anxiety.
Enter resveratrol
Currently, most of the drugs that doctors prescribe for depression and anxiety interact with serotonin or noradrenaline pathways in the brain.
Researchers are trying to find other possible drug targets, and some have turned to a natural compound called resveratrol.
Resveratrol occurs in the skin of grapes and berries, and, most famously, it is in red wine. Over recent years, it has received an increasing amount of attention from medical scientists.
Earlier studies have shown that resveratrol appears to have antidepressant activity in mice and rats.
The latest study, which appears in the journal Neuropharmacology, takes a closer look at the mechanisms contributing to resveratrol's antidepressant activity. The researchers also question whether resveratrol might provide the basis of future treatments for anxiety and depression.
The team, from Xuzhou Medical University in China, paid particular attention to the role of phosphodiesterase 4 (PDE4) and cyclic adenosine monophosphate (cAMP).
