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News Center
One shot may block chemo pain for several weeks
This was the conclusion of new research that tested the effects of a protein, called apolipoprotein A-I binding protein (AIBP), in mice with chemotherapy-induced pain.
Should the approach prove to be effective in humans with chemotherapy pain, it could offer an alternative to opioids, which carry the risk of addiction.
A report on the new study — led by the University of California (UC) San Diego in La Jolla — is now published in the journal Cell Reports.
It describes how one spinal injection of AIBP alleviated chemotherapy-induced pain in mice — without side effects — for 2 months.
Blocks underlying pain mechanism
AIBP binds to a cell surface protein called toll-like receptor 4 (TLR4) that plays a key role in recognizing infection and activating the immune system.
The researchers found that AIPB switched off the mice's TLR4 receptors, effectively preventing and reversing inflammation and cell processes that deal with pain.
